The genomic profile associated with risk of severe forms of COVID-19 in Amazonian native american populations

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dc.contributor.advisor1SANTOS, Ney Pereira Carneiro dos
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1290427033107137pt_BR
dc.contributor.advisor1ORCIDhttps://orcid.org/0000-0001-8087-7037pt_BR
dc.creatorPASTANA, Lucas Favacho
dc.creatorSILVA, Thays Amâncio
dc.creator.Latteshttp://lattes.cnpq.br/6748696670037825pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/7718152147203385pt_BR
dc.date.accessioned2023-08-31T13:23:56Z
dc.date.available2023-08-31T13:23:56Z
dc.date.issued2022
dc.description.abstractGenetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, XCR1, and ABO genes with the risk of severe forms of COVID-19 in Amazonian Native Americans, and to compare the frequencies with continental populations. The study population was composed of 64 Amerindians from the Amazon region of northern Brazil. The difference in frequencies between the populations was analyzed using Fisher’s exact test, and the results were significant when p ≤ 0.05. We investigated 64 polymorphisms in 7 genes; we studied 47 genetic variants that were new or had impact predictions of high, moderate, or modifier. We identified 15 polymorphisms with moderate impact prediction in 4 genes (ABO, CXCR6, FYCO1, and SLC6A20). Among the variants analyzed, 18 showed significant differences in allele frequency in the NAM population when compared to others. We reported two new genetic variants with modifier impact in the Amazonian population that could be studied to validate the possible associations with COVID-19 outcomes. The genomic profile of Amazonian Native Americans may be associated with protection from severe forms of COVID-19. This work provides genomic data that may help forthcoming studies to improve COVID-19 outcomes.pt_BR
dc.identifier.citationPASTANA, Lucas Favacho; SILVA, Thays Amâncio et al. The genomic profile associated with risk of severe forms of COVID-19 in Amazonian native american populations. Journal of Personalized Medicine. [S. l.], v. 12, n. 4, p. 1-12, abr. 2022. Disponível em: https://bdm.ufpa.br:8443/jspui/handle/prefix/6080. Acesso em:.pt_BR
dc.identifier.urihttps://bdm.ufpa.br/handle/prefix/6080
dc.rightsAcesso Abertopt_BR
dc.source.uriDisponível na Internet via correio eletrônico: bibsaude@ufpa.brpt_BR
dc.subjectCOVID-19pt_BR
dc.subjectGenept_BR
dc.subjectRisk factorspt_BR
dc.subjectGenetic variantpt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::MEDICINApt_BR
dc.titleThe genomic profile associated with risk of severe forms of COVID-19 in Amazonian native american populationspt_BR
dc.typeTrabalho de Curso - Graduação - Artigopt_BR

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